that primarily affects movement due to loss of nerve cells – neurons that produce a chemical messenger (neurotransmitter) in the brain called
i.e., neurons in the brain come under extreme pressure from an imbalance between antioxidants and reactive oxygen species (ROS).
‘Sesaminol – a chemical abundantly found in empty and waste-thrown shells of sesame, reveals protective effects against Parkinson’s disease. The discovery of this first-ever naturally occurring medicine in food ingredients may help connect the consumption/production chain in a way where the disease is prevented with natural foods and promote societal health.’
Sesaminol – Natural Medicine against Parkinson’s Disease
It was found that sesaminol protected against neuronal damage by promoting the translocation of a protein called Nrf2 (involved in the response to oxidative stress), in in vitro experiments. Thus the production of intracellular ROS is reduced. Promising results were also seen in in vivo experiments.
The study demonstrated an increase in dopamine levels in the Parkinson’s disease mice models, after feeding them with a diet containing sesaminol for 36 days. Also, a significant increase in motor performance and intestinal motor function was proved by a rotarod performance test.
The team had thus discovered first-ever naturally occurring medicine in food ingredient – sesaminol, that is being found in the naturally occurring waste of the sesame seed industry. Further research of the product in its clinical trial phase may help connect the consumption/production chain in a way where the disease is prevented with natural foods and promote societal health.
Source: Medindia
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